I am into an animation "Kami nomizo shiru sekai" (The World God Only Knows) which my friend recommended.
In order to displace Kake Tama from girls, it is needed to fill their spiritual void by love.
A boy, who is interested in just girls of 2D, was charged with mission to let real girls fall in love, and he complete that mission. This is outline of that animation.
Since the story that "Otaku" is popular with real girls is set, it may seem that the unrealizable wish of "Otaku" is projected into that animation. However, that animation deals with an important existential question for almost people.
In my personal view, spiritual void which becomes hideout of Kake Tama is made by a lack of self-confidence (of course not only that). The feelings of self-denial, self-doubt and meaninglessness of self, make spiritual void.
In that animation, the girls get self-confidence back by love. Because, Love is mutual recognition of self and others, and can be hope of future.
Description of spiritual void of girls remind us that we have same spiritual void, and can offer emotional catharsis. I think it is true value of that animation.